Preformulation Study

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  Physicochemical Properties

  ▪ PKa /LogP, solubility and acid-base, etc
  ▪ Characterization of solid-state properties: crystallinity, crystal shape, thermodynamic properties, hygroscopicity, specific surface area, etc
  ▪ Stability
  ▪ Detection and determination of solvent complexes/hydrates
  
  

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  Single Crystal Culture and Stereostructure Confirmation

  ▪ Screening of solvent for single crystal culture
  ▪ Multiple methods to grow single crystals
  ▪ Confirmation of molecular stereostructure
  

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  Polymorphism Screening and Salt Form Selection

  ▪ Solid state characterization and rough solubility test of initial compounds
  ▪ Screening test and evaluation of polymorphism and salt forms
  ▪ Further evaluation of candidate polymorphs /salt forms
  

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  Excipient Compatibility Study

  ▪ Compatibility of excipients/formulation under accelerated conditions